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I used to think running was a panacea. "If the furnace is hot enough, anything will burn, even Big Macs," as the fictional miler Quenton Cassidy once said. Then, about a decade ago, there was a big surge of doubt about the health effects of running. Most prominent was the suggestion that even modest amounts of running might damage your heart-"One Running Shoe in the Grave," as the Wall Street Journal put it-but running was also accused of broader sins like promoting inflammation, causing muscle loss, and wreaking havoc on blood sugar levels.
As a runner and a journalist, I spent a lot of time trying to understand these claims, and reevaluating my own understanding of running's health effects-a process that continues to this day. Part of that process involved going back to the original research that led us to believe that running is healthy. And to be honest, the evidence wasn't as clear as I'd assumed. Does running (or aerobic exercise more generally) really improve health markers, or is it just that healthy people are more likely to choose to run? Do the benefits max out after a few minutes per day, or do they keep growing? Can you outrun a bad diet?
I have opinions about all these questions, but I no longer assume that the answers are obvious. So I'm always interested in new data, like a recent study in PLoS ONE from the science team at InsideTracker, a company that sells personalized blood testing to track various health biomarkers. The paper offers a peek at the aggregated results of more than 23,000 customers who report various levels of running, divided into three groups: low volume (less than three hours of running per week), medium volume (three to ten hours per week), and high volume (more than ten hours per week). For comparison, they also include results from 4,400 sedentary non-runners, and at the opposite end of the spectrum, 82 professional distance runners.
There are two important caveats to point out before diving into the data. First, this is observational data, not a randomized trial. That makes it hard to determine whether running causes any of the patterns in the data (though, as we'll see below, there are some ways to test our assumptions about causation). Second, this is a self-selected cohort. Even the sedentary group is made up of people who are interested enough in their health that they've decided to spring for a service that starts at $699 for a single battery of blood tests. Since this control group is already fairly healthy, detecting any improvements will be more challenging.
The Raw Data
The journal article (which is free to read online) presents data on 27 different biomarkers that were significantly different between runners and non-runners. I'm just going to pick out a few categories that are particularly interesting.
First, here's HDL (i.e. "good") cholesterol levels, for females (f) and males (m) in each of the five groups: pro runners, high-, medium-, and low-volume amateurs (HVAM, MVAM, and LVAM, respectively), and sedentary people.
The biggest difference is between runners and non-runners: runners have clearly higher levels, which is good. And among the runners, the trend is that more running is associated with higher levels. Similar patterns are seen for LDL ("bad") cholesterol and triglycerides: running is good, and more running is better.
The pattern here is much less pronounced. There's still a significant difference between runners and non-runners, but the dose-response effect of more mileage is smaller in men and non-existent for women. The same is true when looking at HgbA1c levels, which offer an estimate of long-term average blood sugar levels rather than a single snapshot. In that case, there's a more pronounced difference between runners and non-runners, but no dose-response response effect. For blood sugar, then, running is good but more running isn't necessarily better.
One key point: the sedentary control group has remarkably good blood sugar levels, with an average below the prediabetes cutoff. Given that 98 million Americans have prediabetes, this confirms that the control group is already pretty healthy. If you were to compare runners to the average population, you'd probably see a bigger effect.
Another group of biomarkers is associated with chronic low-grade inflammation. The pattern here is a little more complicated, but data on C-reactive protein, white blood cell count, and ferritin collectively suggest that greater volumes of running are associated with lower levels of inflammation. The fact that ferritin is considered a marker of inflammation was a surprise to me, since I think of it as an indicator of iron levels in endurance athletes. But it turns out ferritin levels can mean different things in different contexts.
For most of the biomarkers, there's a fairly smooth trend from sedentary to pro runners. But there are a few examples where the pro runners are noticeably different from everyone else, even the amateurs who claim they're running more than ten hours a week. Most notably, the pro runners tended to have low magnesium levels-an observation that mirrors earlier data from British Olympic track athletes. The British study also found that athletes with a history of tendon problems were most likely to have low magnesium levels, which suggests that it's something to watch for if you're training hard.
Is It All About BMI?
All the results I mentioned above were statistically adjusted for body-mass index, age, and sex. That's important, because there were significant differences in BMI among the groups. Here's that data:
Now, I look at this graph and think, "Yep, all else being equal, the more you run the less you weigh." This used to strike me as a painfully obvious statement. The current scientific consensus, on the other hand, is that exercise is ineffective for weight loss. And it's true that lots of studies have assigned people to exercise, sometimes quite vigorously, and have seen underwhelming results for weight loss. This is a complex topic whose nuances I'll leave for another day, but suffice to say that the new data agrees with my feeling that, if you're running more than an hour a day, you very likely weigh less than you would if you weren't running.
You can get another level of insight by adding in some of the genetic data that InsideTracker also collects from some of its customers. There are a large number of separate gene variants that are associated with higher BMI; by checking which of these variants a given individual has, the researchers calculated a "polygenic risk score" for obesity. In the sedentary group, those with higher risk scores tended to have higher BMI. Among the high-volume and pro runners, in contrast, that trend was flattened: those with higher risk scores had similar BMI to those with lower scores. Though the sample size was too small to draw definitive conclusions (since relatively few customers opted to get genetic testing), the results suggest that running counteracted the gene variants associated with obesity.
The BMI data raises another important question: are all the other apparent health benefits of running just secondary effects of lower BMI? Here they use a cool technique called Mendelian randomization (which I wrote about in another context earlier this year). It's a way of turning a large observational study into a randomized trial. The randomization occurs at birth: as noted above, some people have gene variants that predispose them to have a higher BMI. These variants are randomly distributed, so if people with the low-BMI versions tend to also have better cholesterol scores (for example) regardless of whether or not they run, it suggests that BMI is what's driving the cholesterol scores.
The results of the Mendelian randomization-again limited by low sample numbers-are somewhere in the middle. It does appear that BMI explains much of the group's difference in cholesterol and inflammation levels, for example-but not all of it. For example, gene variants didn't predict LDL levels, suggesting that it's an independent effect of running.
But the closer you look, the blurrier the line between genes and behavior gets. Some of the genes associated with exercise are also associated with motivation and self-control; people who exercise a lot are also more highly motivated to eat healthily; and so on. We're back to the challenge I mentioned at the top: teasing out the independent health effects of going for a run is really hard. The InsideTracker researchers conclude that "a holistic wellness lifestyle approach is in practice the most likely to be most effective toward preventing cardiometabolic disease." That borders on tautological, but their data adds another small brick to the pile of evidence suggesting that endurance exercise, even or perhaps especially in large quantities, is a useful part of that holistic wellness lifestyle.
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Some victories are measured by finish times. Others are defined by the obstacles overcome simply to reach the starting line.
For American Paralympic swimmer Ali Truwit, completing the New York City Marathon represented far more than covering 26.2 miles. It was the culmination of an extraordinary journey of survival, resilience, and unwavering determination that began with a life-altering shark attack just two years earlier.
On a crisp November morning in 2025, Truwit crossed the iconic finish line wearing a carbon-fibre running blade, fulfilling a promise she had made while recovering in a hospital bed after losing her lower left leg. The emotional milestone marked another remarkable chapter in one of the most inspiring comeback stories in modern sport.
The road to that unforgettable finish began only days after Truwit celebrated a major personal achievement. In May 2023, she completed her first marathon in Copenhagen alongside her mother. Just ten days later, while enjoying a graduation trip to Turks and Caicos with former Yale swimming teammate Sophie Pilkinton, tragedy struck.
While the pair were snorkelling, a shark attacked Truwit, severely injuring her left leg. Displaying remarkable courage, the two swam approximately 55 metres back to their boat, where Pilkinton—then a medical student—quickly applied a tourniquet that stopped the bleeding and ultimately saved Truwit's life.
Doctors were forced to amputate her lower left leg on her 23rd birthday.
Even in the darkest moments of recovery, Truwit's determination never disappeared. Reflecting on having recently completed her first marathon, she joked with one of the first responders that at least she had managed to run a marathon before the attack. The responder's simple but powerful reply would remain with her throughout rehabilitation: "You'll run another one."
Those words became a source of hope during the long and demanding road back.
Only weeks after surgery, Truwit began learning to walk on a prosthetic limb before gradually returning to the swimming pool. The process was anything but straightforward. The water that had once been her sanctuary became a source of painful memories, yet she refused to allow fear to define her future.
Her relentless work ethic soon produced extraordinary results.
Less than 16 months after the attack, Truwit represented the United States at the Paris 2024 Paralympic Games, producing a sensational performance to claim both silver and bronze medals. Standing on the Paralympic podium was a powerful reminder of how far she had come in such a short period, and she dedicated those achievements to everyone who had helped save her life.
Still, another dream remained unfinished.
The New York City Marathon carried deep personal significance. It was not merely another endurance event but a symbolic return to the city where her life had changed forever. On November 2, 2025, she lined up in Staten Island accompanied by 13 family members and close friends, all proudly representing her nonprofit foundation, Stronger Than You Think. Among them was Pilkinton, the friend whose quick thinking had preserved her life on that unforgettable day in the Caribbean.
Together, they covered every mile of the marathon before celebrating an emotional finish that Truwit later described as being "over the moon."
Completing a marathon on a carbon-fibre running blade presents challenges far beyond those faced by able-bodied runners. The prosthetic demands greater strength from the hips, core, and remaining leg while requiring exceptional balance, coordination, and endurance. Truwit's preparation combined months of disciplined training, patience, and mental resilience as she effectively taught herself how to run again.
Her story extends well beyond medals and marathon finishes.
Inspired by her own recovery, Truwit founded Stronger Than You Think, a nonprofit organisation dedicated to helping individuals overcome physical and financial barriers following limb loss. Recognising that sports prosthetics can cost tens of thousands of dollars and are often not covered by insurance, the foundation provides financial assistance for prosthetic devices, supports water-safety education, and promotes opportunities within Paralympic sport.
The organisation has already helped provide more than 11 prosthetic limbs, delivered nearly $200,000 in direct support, and funded over 4,000 hours of water-safety lessons benefiting more than 700 young people.
Throughout her journey, Truwit has remained refreshingly honest about the emotional challenges that continue to accompany recovery. She has openly acknowledged that healing is an ongoing process and that grief can still come in waves. Rather than portraying an effortless comeback, she has demonstrated that resilience is built through persistence, even on the hardest days.
Her remarkable transformation resonates far beyond elite sport. While few people will ever experience the trauma she endured, countless runners and athletes understand the frustration of injury, disappointment, or rebuilding after adversity. Truwit's journey serves as a powerful reminder that recovery is rarely linear and that courage is often measured by the willingness to keep moving forward despite uncertainty.
Now looking ahead to the Los Angeles 2028 Paralympic Games, Truwit continues to redefine what is possible. She is no longer known simply as the swimmer who survived a shark attack. She has become a Paralympic medallist, marathon finisher, advocate, and symbol of resilience whose story continues to inspire athletes around the world.
Her journey proves that while life can change in an instant, so too can the strength of the human spirit. Sometimes the greatest triumph is not returning to the person you once were, but discovering someone even stronger than you ever imagined possible.
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Sprint and hurdles superstar Sydney McLaughlin-Levrone has entered an exciting new chapter in her remarkable life, welcoming her first child with husband Andre Levrone. The four-time Olympic champion and women's 400m hurdles world record holder announced the birth of their daughter, Savannah Michelle Levrone, who was born on Sunday, July 12, 2026.
The couple shared the joyful news with an emotional message celebrating the arrival of their daughter and expressing gratitude to everyone who supported them throughout the pregnancy. Sydney described Savannah as "our blessing and our joy," while expressing excitement and faith for the future that lies ahead for their growing family.
The announcement marks a deeply personal milestone for one of the most accomplished athletes of her generation. Renowned for redefining the women's 400m hurdles through a succession of record-breaking performances, McLaughlin-Levrone now embraces a new role beyond the track as a mother.
The timing of the announcement adds another layer of significance. Just days earlier, Sydney reflected on the 10th anniversary of qualifying for her first Olympic Games at only 16 years old—a breakthrough that launched one of the most decorated careers in modern athletics. Ten years later, her journey has come full circle with another life-changing milestone, underscoring that her greatest moments continue to extend beyond sporting success.
The arrival of Savannah Michelle Levrone has been met with an outpouring of congratulations from athletes, fans, and the wider sporting community, who have celebrated the couple as they begin this new chapter together. As Sydney McLaughlin-Levrone steps into motherhood, the athletics world will undoubtedly continue to follow her inspiring journey—both on and off the track.
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Ethiopia's Tsige Gebreselama produced one of the standout road running performances of the season on Sunday, storming to victory at the prestigious Boilermaker Road Race 15K in Utica, New York, with a sensational course record of 47:29.
From the opening kilometers, Gebreselama controlled the race with remarkable composure and precision, maintaining a relentless pace that ultimately erased the previous course record and secured one of the fastest performances ever recorded on the historic course. Her commanding display further reinforced her reputation as one of the world's leading road and distance runners.
The Ethiopian celebration continued as Melknat Wudu crossed the finish line in second place in 47:44, completing a dominant one-two finish for her country. Kenya's Priscah Cherono claimed third in 48:14 after a determined effort, rounding out a world-class podium in a race featuring some of the finest distance runners on the international circuit.
The battle behind the podium remained fiercely competitive. Kenya's Everlyn Kemboi finished fourth in 48:28, narrowly ahead of compatriot Selah Busienei, who clocked 48:31 for fifth. Ethiopia's Netsanet Desta and Alem Nigus Tsadik followed in sixth and seventh respectively, while Kenya's Mercy Cherono secured eighth place.
American athletes also delivered encouraging performances on home roads. Veteran Stephanie Bruce finished ninth in 50:40, with Jackie Gaughan completing the top ten in 51:02 to cap a strong showing for the host nation.
Boilermaker Road Race 15K – Women's Top 10 Results
1. Tsige Gebreselama (Ethiopia) – 47:29 (Course Record)
2. Melknat Wudu (Ethiopia) – 47:44
3. Priscah Cherono (Kenya) – 48:14
4. Everlyn Kemboi (Kenya) – 48:28
5. Selah Busienei (Kenya) – 48:31
6. Netsanet Desta (Ethiopia) – 48:46
7. Alem Nigus Tsadik (Ethiopia) – 48:48
8. Mercy Cherono (Kenya) – 50:23
9. Stephanie Bruce (United States) – 50:40
10. Jackie Gaughan (United States) – 51:02
The women's race combined exceptional depth with remarkable speed, as several athletes broke the 49-minute barrier in a contest that showcased the global strength of elite road running. Gebreselama's record-breaking run now stands as a new benchmark in the rich history of the Boilermaker 15K, adding another memorable chapter to one of the United States' most celebrated road races.
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The Boilermaker 15K is the premier event of Boilermaker Weekend. This world krenowned race is often referred to as the country's best 15K. The Boilermaker 15K is recognized for its entertaining yet challenging course and racing's best post-race party, hosted by the F.X. Matt Brewing Company, featuring Saranac beer and a live concert! With 3 ice and water stops every...
more...Kenya's Alex Matata delivered a sensational performance to claim the men's title at the prestigious Boilermaker Road Race 15K in Utica, New York, producing a dominant run that underlined his growing reputation as one of the world's finest road racers.
Matata surged to victory in an outstanding time of 42:24, mastering the demanding course with a display of strength, speed, and tactical brilliance. His commanding performance secured a memorable triumph in one of the United States' most celebrated road races, adding another significant international victory to his career.
Kenya's success was further highlighted by Kiprono Sitonik, who produced an equally impressive run to finish second in 42:53, completing a remarkable one-two finish for the East African nation. South Africa's Adam Lipschitz rounded out the podium after clocking 43:14 to claim third place following a determined effort.
The race featured a highly competitive international field, with American athletes Reid Buchanan and Hillary Bor finishing fourth and fifth respectively, while another Kenyan, Victor Shitsama, added to his country's strong showing by taking sixth place.
Matata's victory once again showcased Kenya's enduring strength in global road racing, as its athletes continued to dominate major international competitions through exceptional endurance, tactical awareness, and relentless finishing speed. His performance in Utica not only thrilled the spectators lining the streets but also reinforced the depth of Kenyan distance running on the world stage.
Men's Top 10 Results – Boilermaker Road Race 15K
1. Alex Matata (Kenya) – 42:24
2. Kiprono Sitonik (Kenya) – 42:53
3. Adam Lipschitz (South Africa) – 43:14
4. Reid Buchanan (United States) – 43:38
5. Hillary Bor (United States) – 43:40
6. Victor Shitsama (Kenya) – 44:02
7. Futsum Zienasellassie (United States) – 44:32
8. Charlie Sweeney (United States) – 44:37
9. Sam Lawler (United States) – 44:54
10. Tyler Berg (United States) – 45:08
With another major road racing title added to his résumé, Alex Matata continued his impressive 2026 campaign while reinforcing his status as one of the leading names on the international road racing circuit. The Boilermaker 15K once again delivered a high-quality contest, with athletes from across the globe producing memorable performances in one of the United States' most prestigious road races.
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The Boilermaker 15K is the premier event of Boilermaker Weekend. This world krenowned race is often referred to as the country's best 15K. The Boilermaker 15K is recognized for its entertaining yet challenging course and racing's best post-race party, hosted by the F.X. Matt Brewing Company, featuring Saranac beer and a live concert! With 3 ice and water stops every...
more...Eliud Kipchoge's remarkable World Tour continued on Brazilian soil as the Kenyan marathon icon completed the New Balance 42K Porto Alegre Marathon, crossing the finish line in 2:18:39 to place 12th overall during the second stop of his ambitious seven-continent global running tour.
Competing against a strong international field, the two-time Olympic marathon champion displayed the resilience and determination that have defined his legendary career. While the result was not among the victories that have made him one of the greatest marathon runners in history, Kipchoge once again demonstrated the unwavering commitment that continues to inspire athletes and fans across the globe.
Morocco's Zineddine Ouria claimed victory in a superb 2:08:49, with Kipchoge finishing 9 minutes and 50 seconds behind the race winner after navigating the demanding course in Porto Alegre.
Kipchoge began the race with controlled and confident pacing, reaching 5km in 15:34 before passing the halfway mark in 1:05:07. As the race entered its decisive stages, the pace gradually slowed, but the veteran marathoner pressed on with characteristic determination, completing the 42.195-kilometre challenge in 2:18:39.
For many, the story will be told through the finishing position. But for those who truly understand greatness, this journey is about far more than medals, records, or podium finishes. Kipchoge's World Tour is a celebration of the sport itself—an opportunity to connect with runners across every continent, inspire the next generation, and continue living by the philosophy that has become synonymous with his career: "No Human Is Limited."
The Brazilian appearance also carried added significance, coming shortly after Kipchoge was permanently honoured in Porto Alegre with his footprints unveiled at the entrance of Parque Harmonia—a lasting tribute to his extraordinary impact on distance running and his enduring legacy in the sport.
Once a champion. Forever an inspiration. Legends do not stop inspiring when the victories become fewer; they inspire because they never stop showing up. Through every stride, every finish line, and every challenge embraced, Kipchoge continues to prove that true greatness is measured not only by what an athlete wins, but by the lives they touch along the way.
With the second stop of his World Tour now complete, Kipchoge will turn his attention to the next chapter of his global adventure when he lines up at the Melbourne Marathon in Australia this October. Wherever he races, millions will once again follow the journey of a man whose legacy extends far beyond the stopwatch.
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