Hospital Hill Run has helped raise hundreds of thousands of dollars for local charities. Special Olympics of Metro KC was the first official charity partner in 1996. A partnership program, allowing multiple charities to use the race as their own fund raiser, started in 2008. Over the years, more and more charities have used the event to raise awareness and money.

Volunteers have always been the backbone of the Hospital Hill Run. Each year, more and more individuals and groups come out over the course of 4 days to unwrap medals, pack post-race food packets, sort, stack, and pass out t-shirts, distribute bibs, set up and staff aid stations, cheer and steer participants on course, award medals, give wet towels, food, and hydration at the finish line, and then help clean it all up..

The race has grown from the beginning 99 runners to more than 5,000 entries.